Elevated lipogenesis in epithelial stem-like cell confers survival advantage in ductal carcinoma in situ of breast cancer
Upregulation of lipogenesis is a hallmark of cancer and blocking the lipogenic pathway is
known to cause tumor cell death by apoptosis. However, the exact role of lipogenesis in
tumor initiation is as yet poorly understood. We examined the expression profile of key
lipogenic genes in clinical samples of ductal carcinoma in situ (DCIS) of breast cancer and
found that these genes were significantly upregulated in DCIS. We also isolated cancer stem-
like cells (CSCs) from DCIS. com cell line using cell surface markers (CS24− CD44+ ESA+) …
known to cause tumor cell death by apoptosis. However, the exact role of lipogenesis in
tumor initiation is as yet poorly understood. We examined the expression profile of key
lipogenic genes in clinical samples of ductal carcinoma in situ (DCIS) of breast cancer and
found that these genes were significantly upregulated in DCIS. We also isolated cancer stem-
like cells (CSCs) from DCIS. com cell line using cell surface markers (CS24− CD44+ ESA+) …
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